路易 Body 痴呆
Overview
路易 body dementia can occur alone or with other neurodegenerative conditions such as 阿尔茨海默氏症 or 帕金森病. It is the second most frequent cause of dementia in elderly adults and is associated with abnormal structures called 路易-bodies found in certain areas of the brain.
路易 bodies are abnormal protein deposits — smooth, round lumps in the nerve cells of the brain — that disrupt the brain's normal functioning. They're found throughout the outer layer or cerebral cortex of the brain and deep inside the midbrain and brainstem.
Frederich路易, a neurologist and contemporary of Alois Alzheimer, first identified these abnormal protein deposits in 1912.
Researchers don't yet understand if dementia with 路易 bodies is a distinct disease or a variation of 阿尔茨海默氏症 or 帕金森病. Symptoms can mimic those of 帕金森病 or Alzheimer’s disease.
我们对路易体痴呆的研究
As a world leader in the field of dementia disorders, UCSF provides comprehensive assessments and care for people with 路易 body dementia. We work with patients to find the right medications to alleviate 症状. We may also recommend speech therapy to improve communication and physical therapy to stretch and strengthen stiff muscles.
奖 & 识别
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是全国顶尖的十大赌博平台排行榜之一
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加州最好，排名第一. 神经病学全国排名第二 & 神经外科
迹象 & 症状
路易体痴呆的症状包括:
- Progressive cognitive decline, memory loss and confusion
- Fluctuating ability to comprehend and focus attention
- Recurring visual hallucinations that are typically detailed
- Symptoms similar to 帕金森病 such as stiff muscles and shuffling gait.
不像阿尔茨海默病, 哪一种倾向于逐渐发展, 这种疾病往往发病迅速, 在最初的几个月里迅速下降. 晚些时候, there may be some leveling off but 路易 body dementia typically progresses faster than 阿尔茨海默氏症. A patient can survive from five to seven years with the disease.
诊断
路易 body dementia is difficult to diagnose because its 症状 are similar to other conditions. An extensive neurological and neuropsychological evaluation will be conducted, including brain imaging in an effort to identify degeneration of the brain.
和许多痴呆症一样, a definitive diagnosis can only be made with an autopsy when 路易 bodies in brain tissue can be seen.
除了最常见的症状, patients with 路易 body dementia may experience the following:
- Difficult sleeping or physically active during sleep
- 昏厥和周期性的意识丧失
- High sensitivity to drugs used treat hallucinations
- 重复的瀑布
治疗
Because there is no cure for 路易 body dementia, doctors try to treat and manage 症状 of the disease. Medications 用来治疗老年痴呆症 and 帕金森病 have been effective in some patients but must be closely monitored because patients with 路易 body dementia tend to be highly sensitive to drugs that affect the brain and can experience adverse side effects.
Medicatiions are usually initially administered at a low dose and slowly increased over time.
Tranquilizers and anti-psychotic drugs such as haloperidol or thioridazine, are sometimes used to help lessen 症状 such as agitation or hallucinations.
病人 have been especially responsive to cholinesterase inhibitors, 用来治疗老年痴呆症, to improve memory and cognition and reduce hallucinations.
The drug Levodopa or other 帕金森病 medications may be given to treat the 帕金森病-like 症状, to improve muscle stiffness and improve walking.
加州大学旧金山分校健康 medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your provider.
